Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy

Mutations in the SLC13A5 citrate transporter have been linked to epilepsy in humans. In this study the authors generate a new zebrafish model of slc13a5 epilepsy and reveal that in this model, excessive extracellular citrate chelates zinc ions that regulate N…

Plos.org

Deepika Dogra, Van Anh Phan, Sinan Zhang, Cezar Gavrilovici, Nadia DiMarzo, Ankita Narang, Kingsley Ibhazehiebo, Deborah M. Kurrasch

Citation: Dogra D, Phan VA, Zhang S, Gavrilovici C, DiMarzo N, Narang A, et al. (2025) Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC… [+88803 chars]

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